Macrophages, inflammatory cells with peripheral fibrosis and necrosis. Reduction, augmentation, reconstruction, radiation therapy) and isĬharacterized histologically by foamy histiocytes, lipid-laden 14,15 Fat necrosisįat necrosis is a nonsuppurative inflammatory process secondary toĪccidental or surgical trauma (eg, blunt trauma, biopsy, lumpectomy, While a lobulated mass with non-enhancing internal septations (NPV 95%)Īnd persistent (Type-I) kinetics (NPV 94%) suggests benignity. On MRI, a mass with spiculated margins (PPV 88%), rim enhancement (PPVħ9%), or washout (Type-III) kinetics (PPV 87%) suggests malignancy, With a thin echogenic capsule (NPV 95%), circumscribed margin (NPV 90%),Īnd parallel orientation (NPV 78%) are predictive of benignity. Shape (PPV 62%) and non-parallel orientation (PPV 69%), whereas masses Malignancy include masses with spiculated margins (PPV 86%), irregular 8,9,10 Sonographic features predictive of With round or oval shape, circumscribed margins, and low orįat-containing density are likely to be benign (negative predictive Spiculated margins (PPV 81%) and irregular shape (PPV 73%), while masses Mammographic features predictive of malignancy include masses with As a result, radiologists willīecome more familiar with benign breast lesions that mimic breast cancerĪnd gain a better understanding concerning their management. Mammography, ultrasound and/or MRI and that can exhibit imaging features Using case examples, this article will discuss common and uncommonīenign conditions that present as masses or architectural distortion on Work, and added expense to the healthcare system. Lesions is associated with substantial patient anxiety, lost time from Work-up and in some cases, biopsy or even surgery for these benign Surgical excision is subsequently performed. There is radiology-pathology discordance following image-guided biopsy, Imaging which undergo percutaneous biopsy are benign. Leading cause of death in women, the majority of findings discovered on Annual screening with MRI and mammographyīeginning at age 30 for high-risk women is felt to be effective.Īlthough breast cancer is relatively common and remains the second Mammography for women who are at increased lifetime risk of breastĬancer of greater than 20-25%. Magnetic resonance imaging (MRI) is recommended in addition to 2,3,4 Ultrasound, though an important supplement to mammography and now used to screen women with dense breast tissue, 5 has a relatively high false positive rate. Recalled, approximately 12% of women necessitate biopsy and more thanĦ0% of biopsies are benign yielding an average 4.8% positive predictive With a sensitivity of 60-90% and an overall specificity ofġ with the average recall rate from screening being 9.8%. Mammography is the gold standard for early detection of breast cancer
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